Reactome | Assembly of telomerase RNP

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Assembly of telomerase RNP Show undefined attributes

authored	[InstanceEdit:877326] Swanberg, SE, O'Hare, TH, Delany, ME, 2010-06-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:417104] D'Eustachio, P, 2009-04-09 20:58:55
dbId	417114
displayName	Assembly of telomerase RNP
edited	[InstanceEdit:418137] D'Eustachio, P, 2009-04-15 21:34:46
eventOf	[Pathway:R-GGA-417076] Assembly of telomerase and telomere extension - Gallus gallus
followingEvent	[Reaction:R-GGA-417077] Recruitment of telomerase RNP to a telomeric chromosome end - Gallus gallus
input	2 × [EntityWithAccessionedSequence:R-GGA-417112] DKC1 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-417101] TERC RNA [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-GGA-417079] TERT [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:417111] Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity [LiteratureReference:417094] Secondary structure of vertebrate telomerase RNA [LiteratureReference:417089] Protein composition of catalytically active human telomerase from immortal cells [LiteratureReference:417107] Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line [LiteratureReference:417102] Mechanism of telomerase activation by v-Rel and its contribution to transformation [LiteratureReference:417080] Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly [LiteratureReference:418237] Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10 [LiteratureReference:418255] Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Assembly of telomerase RNP TERC RNA + 2 TERT + 2 DKC1 (dyskerin) => telomerase RNP
output	[Complex:R-GGA-417084] telomerase RNP [nucleoplasm]
regulatedBy	[PositiveRegulation:R-GGA-417110] Positive regulation by 'RUVBL1 [nucleoplasm]' [PositiveRegulation:R-GGA-418259] Positive regulation by 'NHP2 [nucleoplasm]'
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-417114
summation	[Summation:417115] The telomerase RNP complex is formed in the nucleoplasm from...

Referrals

(hasEvent)	[Pathway:R-GGA-417076] Assembly of telomerase and telomere extension
(precedingEvent)	[Reaction:R-GGA-417077] Recruitment of telomerase RNP to a telomeric chromosome end