Reactome | UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

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UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 Show undefined attributes

catalystActivity	[CatalystActivity:10783729] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
category	transition
compartment	[Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10783731
displayName	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2
eventOf	[Pathway:R-GGA-9793242] SUMOylation of nuclear envelope proteins - Gallus gallus [Pathway:R-GGA-9615933] Postmitotic nuclear pore complex (NPC) reformation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9624893] RAN stimulates fusion of nuclear envelope (NE) membranes - Gallus gallus
inferredFrom	[Reaction:R-HSA-3000449] UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 - Homo sapiens
input	[Complex:R-GGA-9626018] RANGAP1 homodimer [nuclear envelope] 2 × [Complex:R-GGA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 Conjugation of SUMO1 to RANGAP1
output	[Complex:R-GGA-9624892] SUMO1:RANGAP1 homodimer [nuclear envelope] 2 × [EntityWithAccessionedSequence:R-GGA-912481] UBE2I [nucleoplasm]
precedingEvent	[Reaction:R-GGA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-3000449
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9793242] SUMOylation of nuclear envelope proteins [Pathway:R-GGA-9615933] Postmitotic nuclear pore complex (NPC) reformation
(precedingEvent)	[Reaction:R-GGA-9624893] RAN stimulates fusion of nuclear envelope (NE) membranes
(inferredTo)	[Reaction:R-HSA-3000449] UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

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