Reactome | Transfer of SUMO1 from E1 to UBE2I (UBC9)

Schema > Reaction > Entries

Transfer of SUMO1 from E1 to UBE2I (UBC9) Show undefined attributes

catalystActivity	[CatalystActivity:10783496] SUMO transferase activity of UBA2:SAE1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10783502
displayName	Transfer of SUMO1 from E1 to UBE2I (UBC9)
eventOf	[Pathway:R-GGA-3065678] SUMO is transferred from E1 to E2 (UBE2I, UBC9) - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-4085350] SUMOylation of UBE2I with SUMO1 - Gallus gallus [Reaction:R-GGA-4551683] SUMOylation of TOPORS with SUMO1 - Gallus gallus [Reaction:R-GGA-3968362] SUMOylation of PIAS4 with SUMO1 - Gallus gallus [Reaction:R-GGA-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 - Gallus gallus [Reaction:R-GGA-3000434] PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 - Gallus gallus [Reaction:R-GGA-5228523] RANBP2 SUMOylates MDM2 with SUMO1 - Gallus gallus [Reaction:R-GGA-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 - Gallus gallus [Reaction:R-GGA-4086083] SUMOylation of ING2 with SUMO1 - Gallus gallus [Reaction:R-GGA-4086088] SUMOylation of NPM1 with SUMO1 - Gallus gallus [Reaction:R-GGA-3900047] SUMOylation of DDX17 with SUMO1 - Gallus gallus [Reaction:R-GGA-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 - Gallus gallus [Reaction:R-GGA-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 - Gallus gallus [Reaction:R-GGA-4086036] PIAS1,3 SUMOylate NRIP1 with SUMO1 - Gallus gallus [Reaction:R-GGA-3900177] SUMOylation of DDX5 with SUMO1 - Gallus gallus [Reaction:R-GGA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 - Gallus gallus [Reaction:R-GGA-3899291] SUMOylation of EP300 with SUMO1 - Gallus gallus [Reaction:R-GGA-3108209] PRC1 SUMOylates CTBP1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4085347] PIAS1 SUMOylates SAFB with SUMO1 - Gallus gallus [Reaction:R-GGA-3900070] SUMOylation of MKL1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4085992] SUMOylation of DAXX with SUMO1 - Gallus gallus [Reaction:R-GGA-4085994] TOPORS SUMOylates SIN3A with SUMO1 - Gallus gallus [Reaction:R-GGA-4090284] SUMOylation of HIPK2 with SUMO1 - Gallus gallus [Reaction:R-GGA-4085296] SUMOylation of NCOA1 with SUMO1 - Gallus gallus [Reaction:R-GGA-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 - Gallus gallus [Reaction:R-GGA-4641342] SUMOylation of TOP2A with SUMO1 - Gallus gallus [Reaction:R-GGA-4641345] SUMOylation of TOP2B with SUMO1 - Gallus gallus [Reaction:R-GGA-4641362] SUMOylation of TOP1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4615910] SUMOylation of PCNA with SUMO1 - Gallus gallus [Reaction:R-GGA-3108212] SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 - Gallus gallus [Reaction:R-GGA-4568863] SUMOylation of RAD52 with SUMO1 - Gallus gallus [Reaction:R-GGA-4568848] PIAS1,2-1 SUMOylates XRCC4 with SUMO1 - Gallus gallus [Reaction:R-GGA-5228508] RANBP2 SUMOylates PML with SUMO1 - Gallus gallus [Reaction:R-GGA-3000383] UBE2I, HDAC7 SUMOylate PML with SUMO1 - Gallus gallus [Reaction:R-GGA-4551604] PIAS4 SUMOylates PARP1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4551724] PIAS4 SUMOylates HERC2 with SUMO1 - Gallus gallus [Reaction:R-GGA-4551661] PIAS4 SUMOylates RNF168 with SUMO1 - Gallus gallus [Reaction:R-GGA-4570528] SUMOylation of XPC with SUMO1 - Gallus gallus [Reaction:R-GGA-4551648] SUMOylation of TDG with SUMO1 - Gallus gallus [Reaction:R-GGA-2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4341048] SUMOylation of RXRA with SUMO1 - Gallus gallus [Reaction:R-GGA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs - Gallus gallus [Reaction:R-GGA-3000449] UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 - Gallus gallus [Reaction:R-GGA-4755479] SUMOylation of NFKB2 with SUMO1 - Gallus gallus [Reaction:R-GGA-4755411] PIAS4 SUMOylates IKBKG with SUMO1 - Gallus gallus [Reaction:R-GGA-4755478] TOPORS SUMOylates IKBKE with SUMO1 - Gallus gallus [Reaction:R-GGA-4656914] SUMOylation of NFKBIA with SUMO1 - Gallus gallus [Reaction:R-GGA-3234094] SUMOylation of TFAP2C with SUMO1 - Gallus gallus [Reaction:R-GGA-9926476] UBE2I sumoylates MITF-M - Gallus gallus [Reaction:R-GGA-4551655] CBX4 SUMOylates BMI1 in PRC1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4570496] SUMOylation of Histone H4 with SUMO1 - Gallus gallus [Reaction:R-GGA-8956365] ZBED1 (DREF) SUMOylates CHD3 with SUMO1 - Gallus gallus [Reaction:R-GGA-4615872] RANBP2 SUMOylates HDAC4 with SUMO1 - Gallus gallus [Reaction:R-GGA-4615905] PIAS1 SUMOylates SATB1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4615873] PIAS2-2 SUMOylates SUZ12 with SUMO1 - Gallus gallus [Reaction:R-GGA-4616015] SUMOylation of HDAC2 with SUMO1 - Gallus gallus [Reaction:R-GGA-4551727] CBX4 SUMOylates CBX4 in PRC1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4615889] SUMOylation of HDAC1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4655431] SUMOyation of DNMT1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4655374] SUMOylation of DNMT3B with SUMO1 - Gallus gallus [Reaction:R-GGA-4570467] SUMOylation of NOP58 with SUMO1 - Gallus gallus [Reaction:R-GGA-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 - Gallus gallus [Reaction:R-GGA-3232162] PIAS3 SUMOylates MITF with SUMO1 - Gallus gallus [Reaction:R-GGA-3247493] PIAS1 SUMOylates SP3 with SUMO1 - Gallus gallus [Reaction:R-GGA-2997723] PIAS4 SUMOylates TP53BP1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4719436] PIAS2,3,4 SUMOylate RORA with SUMO1 - Gallus gallus [Reaction:R-GGA-4719424] PIAS1 SUMOylates THRB with SUMO1 - Gallus gallus [Reaction:R-GGA-4341070] PIAS4 SUMOylates PPARA with SUMO1 - Gallus gallus [BlackBoxEvent:R-GGA-4755419] SUMOylation of NR1H4 with SUMO1 - Gallus gallus [Reaction:R-GGA-4341073] PIAS3 SUMOylates PGR with SUMO1 - Gallus gallus [Reaction:R-GGA-4090408] PIAS1,3 SUMOylate ESR1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 - Gallus gallus [Reaction:R-GGA-4341016] PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 - Gallus gallus [Reaction:R-GGA-4719447] PIAS2-2 SUMOylates THRA with SUMO1 - Gallus gallus [Reaction:R-GGA-4341025] SUMOylation of NR3C1 (GR) with SUMO1 - Gallus gallus [Reaction:R-GGA-4090390] PIAS1,2-1 SUMOylates AR with SUMO1 - Gallus gallus [Reaction:R-GGA-4755494] PIAS1,2-1 SUMOylate NR5A2 with SUMO1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
input	[Complex:R-GGA-2993793] SUMO1:UBA2:SAE1 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-912481] UBE2I [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Transfer of SUMO1 from E1 to UBE2I (UBC9)
output	[Complex:R-GGA-2993783] SUMO1:C93-UBE2I [nucleoplasm] [Complex:R-GGA-2990843] UBA2:SAE1 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-2990833] Conjugation of SUMO1 to UBA2:SAE1 - Gallus gallus
regulatedBy	[PositiveRegulation:10783503] Positive regulation by 'RWDD3 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2993780
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-4085350] SUMOylation of UBE2I with SUMO1 [Reaction:R-GGA-4551683] SUMOylation of TOPORS with SUMO1 [Reaction:R-GGA-3968362] SUMOylation of PIAS4 with SUMO1 [Reaction:R-GGA-4551649] RANBP2 SUMOylates RANBP2 with SUMO1 [Reaction:R-GGA-3000434] PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 [Reaction:R-GGA-5228523] RANBP2 SUMOylates MDM2 with SUMO1 [Reaction:R-GGA-3782535] TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 [Reaction:R-GGA-4086083] SUMOylation of ING2 with SUMO1 [Reaction:R-GGA-4086088] SUMOylation of NPM1 with SUMO1 [Reaction:R-GGA-3900047] SUMOylation of DDX17 with SUMO1 [Reaction:R-GGA-4085331] PIAS2-1 SUMOylates PARK7 with SUMO1 [Reaction:R-GGA-3927824] PRC1 SUMOylates CASP8AP2 with SUMO1 [Reaction:R-GGA-4086036] PIAS1,3 SUMOylate NRIP1 with SUMO1 [Reaction:R-GGA-3900177] SUMOylation of DDX5 with SUMO1 [Reaction:R-GGA-5228521] PIAS1,4 SUMOylate CASP8AP2 with SUMO1 [Reaction:R-GGA-3899291] SUMOylation of EP300 with SUMO1 [Reaction:R-GGA-3108209] PRC1 SUMOylates CTBP1 with SUMO1 [Reaction:R-GGA-4085347] PIAS1 SUMOylates SAFB with SUMO1 [Reaction:R-GGA-3900070] SUMOylation of MKL1 with SUMO1 [Reaction:R-GGA-4085992] SUMOylation of DAXX with SUMO1 [Reaction:R-GGA-4085994] TOPORS SUMOylates SIN3A with SUMO1 [Reaction:R-GGA-4090284] SUMOylation of HIPK2 with SUMO1 [Reaction:R-GGA-4085296] SUMOylation of NCOA1 with SUMO1 [Reaction:R-GGA-3296126] CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 [Reaction:R-GGA-4641342] SUMOylation of TOP2A with SUMO1 [Reaction:R-GGA-4641345] SUMOylation of TOP2B with SUMO1 [Reaction:R-GGA-4641362] SUMOylation of TOP1 with SUMO1 [Reaction:R-GGA-4615910] SUMOylation of PCNA with SUMO1 [Reaction:R-GGA-3108212] SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 [Reaction:R-GGA-4568863] SUMOylation of RAD52 with SUMO1 [Reaction:R-GGA-4568848] PIAS1,2-1 SUMOylates XRCC4 with SUMO1 [Reaction:R-GGA-5228508] RANBP2 SUMOylates PML with SUMO1 [Reaction:R-GGA-3000383] UBE2I, HDAC7 SUMOylate PML with SUMO1 [Reaction:R-GGA-4551604] PIAS4 SUMOylates PARP1 with SUMO1 [Reaction:R-GGA-4551724] PIAS4 SUMOylates HERC2 with SUMO1 [Reaction:R-GGA-4551661] PIAS4 SUMOylates RNF168 with SUMO1 [Reaction:R-GGA-4570528] SUMOylation of XPC with SUMO1 [Reaction:R-GGA-4551648] SUMOylation of TDG with SUMO1 [Reaction:R-GGA-2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 [Reaction:R-GGA-4341048] SUMOylation of RXRA with SUMO1 [Reaction:R-GGA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs [Reaction:R-GGA-3000449] UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 [Reaction:R-GGA-4755479] SUMOylation of NFKB2 with SUMO1 [Reaction:R-GGA-4755411] PIAS4 SUMOylates IKBKG with SUMO1 [Reaction:R-GGA-4755478] TOPORS SUMOylates IKBKE with SUMO1 [Reaction:R-GGA-4656914] SUMOylation of NFKBIA with SUMO1 [Reaction:R-GGA-3234094] SUMOylation of TFAP2C with SUMO1 [Reaction:R-GGA-9926476] UBE2I sumoylates MITF-M [Reaction:R-GGA-4551655] CBX4 SUMOylates BMI1 in PRC1 with SUMO1 [Reaction:R-GGA-4570496] SUMOylation of Histone H4 with SUMO1 [Reaction:R-GGA-8956365] ZBED1 (DREF) SUMOylates CHD3 with SUMO1 [Reaction:R-GGA-4615872] RANBP2 SUMOylates HDAC4 with SUMO1 [Reaction:R-GGA-4615905] PIAS1 SUMOylates SATB1 with SUMO1 [Reaction:R-GGA-4615873] PIAS2-2 SUMOylates SUZ12 with SUMO1 [Reaction:R-GGA-4616015] SUMOylation of HDAC2 with SUMO1 [Reaction:R-GGA-4551727] CBX4 SUMOylates CBX4 in PRC1 with SUMO1 [Reaction:R-GGA-4615889] SUMOylation of HDAC1 with SUMO1 [Reaction:R-GGA-4655431] SUMOyation of DNMT1 with SUMO1 [Reaction:R-GGA-4655374] SUMOylation of DNMT3B with SUMO1 [Reaction:R-GGA-4570467] SUMOylation of NOP58 with SUMO1 [Reaction:R-GGA-3968414] UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 [Reaction:R-GGA-3232162] PIAS3 SUMOylates MITF with SUMO1 [Reaction:R-GGA-3247493] PIAS1 SUMOylates SP3 with SUMO1 [Reaction:R-GGA-2997723] PIAS4 SUMOylates TP53BP1 with SUMO1 [Reaction:R-GGA-4090281] PIAS1,2-1 SUMOylate HIC1 with SUMO1 [Reaction:R-GGA-4719436] PIAS2,3,4 SUMOylate RORA with SUMO1 [Reaction:R-GGA-4719424] PIAS1 SUMOylates THRB with SUMO1 [Reaction:R-GGA-4341070] PIAS4 SUMOylates PPARA with SUMO1 [BlackBoxEvent:R-GGA-4755419] SUMOylation of NR1H4 with SUMO1 [Reaction:R-GGA-4341073] PIAS3 SUMOylates PGR with SUMO1 [Reaction:R-GGA-4090408] PIAS1,3 SUMOylate ESR1 with SUMO1 [Reaction:R-GGA-4546386] PIAS1,3 SUMOylates NR5A1 with SUMO1 [Reaction:R-GGA-4341016] PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 [Reaction:R-GGA-4719447] PIAS2-2 SUMOylates THRA with SUMO1 [Reaction:R-GGA-4341025] SUMOylation of NR3C1 (GR) with SUMO1 [Reaction:R-GGA-4090390] PIAS1,2-1 SUMOylates AR with SUMO1 [Reaction:R-GGA-4755494] PIAS1,2-1 SUMOylate NR5A2 with SUMO1
(inferredTo)	[Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9)
(hasEvent)	[Pathway:R-GGA-3065678] SUMO is transferred from E1 to E2 (UBE2I, UBC9)

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