Reactome | Rad51 assembly at the DNA-damage sites on the chromatin

Schema > Polymerisation > Entries

Rad51 assembly at the DNA-damage sites on the chromatin Show undefined attributes

authored	[InstanceEdit:209713] Saxena, A, 2008-01-04 18:30:50
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:265962] Saxena, A, 2008-04-21 13:32:36
dbId	265940
displayName	Rad51 assembly at the DNA-damage sites on the chromatin
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
eventOf	[Pathway:R-GGA-351433] ATM mediated phosphorylation of repair proteins - Gallus gallus
input	[EntityWithAccessionedSequence:R-GGA-216957] phospho-RAD51 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:265961] Association of BRCA1 with Rad51 in mitotic and meiotic cells [LiteratureReference:265886] BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway [LiteratureReference:265918] CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair [LiteratureReference:265986] In search of the tumour-suppressor functions of BRCA1 and BRCA2 [LiteratureReference:265994] Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes [LiteratureReference:265856] Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 [LiteratureReference:265860] Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Rad51 assembly at the DNA-damage sites on the chromatin
output	[Polymer:R-GGA-265869] Polymerization of phospho-RAD51as foci [nucleoplasm]
precedingEvent	[Reaction:R-GGA-217013] Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members - Gallus gallus
regulatedBy	[PositiveRegulation:R-GGA-265838] Positive regulation by 'BRCA2 [nucleoplasm]' [PositiveRegulation:R-GGA-265935] Positive regulation by 'BRCA1 [nucleoplasm]'
regulationReference	[RegulationReference:9641999] Positive regulation by 'BRCA1 [nucleoplasm]' Brca1 in immunoglobulin gene conversion and somatic hypermutation [RegulationReference:9642524] Positive regulation by 'BRCA2 [nucleoplasm]' Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2
releaseDate	2009-06-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
schemaClass	Polymerisation
species	[Species:49591] Gallus gallus
stId	R-GGA-265940
summation	[Summation:265810] Homologous recombination in vertebrates is catalyzed by Rad5...

Referrals

(hasEvent)

[Pathway:R-GGA-351433] ATM mediated phosphorylation of repair proteins