Reactome | HYAL2 hydrolyses HA into 20kDa fragments

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HYAL2 hydrolyses HA into 20kDa fragments Show undefined attributes

catalystActivity	[CatalystActivity:10779762] hyalurononglucosaminidase activity of HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10779764
displayName	HYAL2 hydrolyses HA into 20kDa fragments
eventOf	[Pathway:R-GGA-2160916] Hyaluronan degradation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-2160892] HYAL2 hydrolyses HA into 20kDa fragments - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-GGA-2160889] HA:HAR:HYAL2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	HYAL2 hydrolyses HA into 20kDa fragments
output	[Polymer:R-ALL-2160894] (HA)50 [plasma membrane] [Complex:R-GGA-9954181] HAR:HYAL2 [plasma membrane]
precedingEvent	[Reaction:R-GGA-2160915] Receptor-mediated uptake of HA - Gallus gallus
regulatedBy	[PositiveRegulation:10779765] Positive regulation by 'SLC9A1:p-CHP:Ca2+ [plasma membrane]' [PositiveRegulation:9954182] Positive regulation by 'H+ [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-2160892
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2160916] Hyaluronan degradation
(inferredTo)	[BlackBoxEvent:R-HSA-2160892] HYAL2 hydrolyses HA into 20kDa fragments

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