Reactome | Factor H displaces Bb in Cb:Bb complex

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Factor H displaces Bb in Cb:Bb complex Show undefined attributes

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
dbId	2132271
displayName	Factor H displaces Bb in Cb:Bb complex
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132281] Regulation of complement cascades - Gallus gallus
followingEvent	[Reaction:R-GGA-2132260] Complement factor I inactivates surface-bound C3b - Gallus gallus
inferredFrom	[Reaction:R-HSA-977605] Factor H displaces Bb - Homo sapiens
input	[Complex:R-GGA-2132200] C3b:Bb [plasma membrane] [EntityWithAccessionedSequence:R-GGA-2132241] CFH [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2314669] Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Factor H displaces Bb in Cb:Bb complex
output	[Complex:R-GGA-2132251] CFH:C3b [plasma membrane] [EntityWithAccessionedSequence:R-GGA-2132131] factor Bb [extracellular region]
precedingEvent	[Reaction:R-GGA-2132061] Complement factor B binds to surface-bound C3b fragment - Gallus gallus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2132271
summation	[Summation:2859021] Factor H accelerates the decay of existing C3/5 convertases ...

Referrals

(hasEvent)	[Pathway:R-GGA-2132281] Regulation of complement cascades
(precedingEvent)	[Reaction:R-GGA-2132260] Complement factor I inactivates surface-bound C3b
(inferredTo)	[Reaction:R-HSA-977605] Factor H displaces Bb

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