Reactome | Complement factor I inactivates surface-bound C3b

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Complement factor I inactivates surface-bound C3b Show undefined attributes

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
catalystActivity	[CatalystActivity:2132268] serine-type endopeptidase activity of CFI [extracellular region]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
dbId	2132260
displayName	Complement factor I inactivates surface-bound C3b
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132281] Regulation of complement cascades - Gallus gallus
inferredFrom	[Reaction:R-HSA-977371] Factor I inactivates Factor H-boundC3b - Homo sapiens
input	[Complex:R-GGA-2132251] CFH:C3b [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2409058] Analysis of binding sites on complement factor I that are required for its activity [LiteratureReference:977617] Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46) [LiteratureReference:977604] Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity [LiteratureReference:2409064] Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Complement factor I inactivates surface-bound C3b
output	[EntityWithAccessionedSequence:R-GGA-2132239] C3f [extracellular region] [EntityWithAccessionedSequence:R-GGA-2132241] CFH [extracellular region] [Complex:R-GGA-2132290] iC3b [extracellular region]
precedingEvent	[Reaction:R-GGA-2132277] Complement factor H binds to surface-bound C3b - Gallus gallus [Reaction:R-GGA-2132271] Factor H displaces Bb in Cb:Bb complex - Gallus gallus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2132260
summation	[Summation:2409055] Complement factor I (CFI) is a serine protease that inhibits...

Referrals

(hasEvent)	[Pathway:R-GGA-2132281] Regulation of complement cascades
(inferredTo)	[Reaction:R-HSA-977371] Factor I inactivates Factor H-boundC3b

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