Reactome | Complement factor H binds to C3b

Schema > Reaction > Entries

authored	[InstanceEdit:2869458] Shamovsky, V, 2012-12-20
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2132292] Shamovsky, V, 2012-02-21
dbId	2132261
displayName	Complement factor H binds to C3b
edited	[InstanceEdit:5149549] Shamovsky, V, 2013-11-19
eventOf	[Pathway:R-GGA-2132281] Regulation of complement cascades - Gallus gallus
followingEvent	[Reaction:R-GGA-2132276] Complement factor I inactivates C3b - Gallus gallus
inferredFrom	[Reaction:R-HSA-976768] Factor H binds to C3b - Homo sapiens
input	[Complex:R-GGA-2132189] C3b [extracellular region] [EntityWithAccessionedSequence:R-GGA-2132241] CFH [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2314669] Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Complement factor H binds to C3b
output	[Complex:R-GGA-2132240] CFH:C3b [extracellular region]
precedingEvent	[Reaction:R-GGA-2173323] Cleavage of C3 by fluid-phase C3i:factor B - Gallus gallus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562608] D'Eustachio, P, 2012-11-06 [InstanceEdit:3006589] Jupe, S, 2013-01-31
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-2132261
summation	[Summation:2530574] Mammalian factor H (CFH or FH) can bind both fluid phase and...

(hasEvent)	[Pathway:R-GGA-2132281] Regulation of complement cascades
(precedingEvent)	[Reaction:R-GGA-2132276] Complement factor I inactivates C3b
(inferredTo)	[Reaction:R-HSA-976768] Factor H binds to C3b

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