Complement factor H binds to C3b

Stable Identifier
R-GGA-2132261
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Complement factor H binds to C3b
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mammalian factor H (CFH or FH) can bind both fluid phase and surface-bound C3b. CFH binding to extracellular C3b has the effect of sequestering C3b, preventing further activation of the complement cascade. CFH can also act as a cofactor for factor I, leading to the cleavage and inactivation of bound C3b.

The chicken events of CFH activity have not been verified experimentally but are inferred from the orthologous human events. Predicted chicken complement factor H shows 38% amino acid sequence identity with human CFH.

Literature References
PubMed ID Title Journal Year
10779780 Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement

Pangburn, MK, Pangburn, KL, Koistinen, V, Meri, S, Sharma, AK

J. Immunol. 2000
Participants
Input
Output
Participates
as an event of
Inferred From
Factor H binds to C3b (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
Cite Us!