Reactome | PRC2 methylates histones and DNA

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PRC2 methylates histones and DNA Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826505
displayName	PRC2 methylates histones and DNA
eventOf	[Pathway:R-GGA-212165] Epigenetic regulation of gene expression - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24867] negative regulation of gene expression, epigenetic
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-GGA-212252] Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin - Gallus gallus [Reaction:R-GGA-212263] PRC2 trimethylates histone H3 at lysine-27 - Gallus gallus [Reaction:R-GGA-212222] PRC2 recruits DNA methyltransferases - Gallus gallus [BlackBoxEvent:R-GGA-212269] DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 - Gallus gallus
inferredFrom	[Pathway:R-HSA-212300] PRC2 methylates histones and DNA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PRC2 methylates histones and DNA Methylation of Histones and DNA by Polycomb Repressive Complex 2 (PRC2)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-212300
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-212165] Epigenetic regulation of gene expression
(inferredTo)	[Pathway:R-HSA-212300] PRC2 methylates histones and DNA

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