Reactome | Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3

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Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 Show undefined attributes

catalystActivity	[CatalystActivity:10746569] protein serine/threonine kinase activity of p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10746581
displayName	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
eventOf	[Pathway:R-GGA-196299] Beta-catenin phosphorylation cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-195300] Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-195305] p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
precedingEvent	[Reaction:R-GGA-195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 - Gallus gallus
regulatedBy	[NegativeRegulation:10746582] Negative regulation by 'FRAT1,2:GSK3beta [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-195283
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196299] Beta-catenin phosphorylation cascade
(precedingEvent)	[Reaction:R-GGA-195300] Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
(inferredTo)	[Reaction:R-HSA-195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3

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