Reactome | phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

Schema > Reaction > Entries

phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate Show undefined attributes

catalystActivity	[CatalystActivity:10740966] CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10744168
displayName	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate
eventOf	[Pathway:R-GGA-177162] Conjugation of phenylacetate with glutamine - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9971063] GLYAT-like proteins transfer glycine to phenylacetyl-CoA - Gallus gallus
inferredFrom	[Reaction:R-HSA-177157] phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-177153] phenylacetate [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate Synthesis of phenylacetyl CoA from phenylacetate and Coenzyme A
output	[SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-177137] phenylacetyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-177157
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-9971063] GLYAT-like proteins transfer glycine to phenylacetyl-CoA
(hasEvent)	[Pathway:R-GGA-177162] Conjugation of phenylacetate with glutamine
(inferredTo)	[Reaction:R-HSA-177157] phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

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