Reactome | Stalling of DNA replication fork and RPA binding

Schema > Reaction > Entries

Stalling of DNA replication fork and RPA binding Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10743997
displayName	Stalling of DNA replication fork and RPA binding
eventOf	[Pathway:R-GGA-176187] Activation of ATR in response to replication stress - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-176101] Recruitment of Rad17-RFC complex to DNA - Gallus gallus [Reaction:R-GGA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
inferredFrom	[Reaction:R-HSA-176175] Stalling of DNA replication fork and RPA binding - Homo sapiens
input	[OtherEntity:R-ALL-176104] Persistent single-stranded DNA [nucleoplasm] [Complex:R-GGA-68462] RPA heterotrimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Stalling of DNA replication fork and RPA binding
output	[Complex:R-GGA-176293] RPA complexed to ssDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-176175
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-176187] Activation of ATR in response to replication stress
(precedingEvent)	[Reaction:R-GGA-176101] Recruitment of Rad17-RFC complex to DNA [Reaction:R-GGA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex
(inferredTo)	[Reaction:R-HSA-176175] Stalling of DNA replication fork and RPA binding

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