Reactome | P4HB [endoplasmic reticulum lumen]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10811289] protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen]
compartment	[Compartment:17957] endoplasmic reticulum lumen
componentOf	[Complex:R-GGA-2022120] P4HB:Collagen propeptides [endoplasmic reticulum lumen] - Gallus gallus [Complex:R-GGA-174681] MTTP:PDI:lipid complex [endoplasmic reticulum lumen] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-9817575] ERO1B oxidizes P4HB - Gallus gallus [Reaction:R-GGA-5358336] P4HB forms mixed disulphides with Hh precursors - Gallus gallus [Reaction:R-GGA-3341296] GPX7,8 catalyze peroxidation of P4HB (PDI) - Gallus gallus [Reaction:R-GGA-2002460] P4HB binds Collagen chains - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10743839
displayName	P4HB [endoplasmic reticulum lumen]
endCoordinate	508
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-174692] P4HB [endoplasmic reticulum lumen] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-GGA-8956956] FAM20C substrates [endoplasmic reticulum lumen] - Gallus gallus
name	P4HB P4HB A0A8V1AL50
producedByEvent	[Reaction:R-GGA-264997] P4HB mediates disulfide bond formation in Proinsulin - Gallus gallus [Reaction:R-GGA-5358340] Autoproteolytic cleavage of Hh precursors - Gallus gallus
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8V1AL50] UniProt:A0A8V1AL50
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49591] Gallus gallus
stId	R-GGA-174692
startCoordinate	18

(input)	[Reaction:R-GGA-9817575] ERO1B oxidizes P4HB [Reaction:R-GGA-2002460] P4HB binds Collagen chains [Reaction:R-GGA-5358336] P4HB forms mixed disulphides with Hh precursors [Reaction:R-GGA-3341296] GPX7,8 catalyze peroxidation of P4HB (PDI)
(output)	[Reaction:R-GGA-264997] P4HB mediates disulfide bond formation in Proinsulin [Reaction:R-GGA-5358340] Autoproteolytic cleavage of Hh precursors
(physicalEntity)	[CatalystActivity:10811289] protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen]
(hasComponent)	[Complex:R-GGA-2022120] P4HB:Collagen propeptides [endoplasmic reticulum lumen] [Complex:R-GGA-5490380] NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen] [Complex:R-GGA-174681] MTTP:PDI:lipid complex [endoplasmic reticulum lumen]
(hasMember)	[DefinedSet:R-GGA-8956956] FAM20C substrates [endoplasmic reticulum lumen]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-174692] P4HB [endoplasmic reticulum lumen]