Reactome | factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

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factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain Show undefined attributes

category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10740005
displayName	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
eventOf	[Pathway:R-GGA-9769733] Fibrin formation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-9921091] ?IIb?3:fibrin multimer ->?IIb?3:fibrin multimer, crosslinked + NH4+ - Gallus gallus
inferredFrom	[Reaction:R-HSA-140847] factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain - Homo sapiens
input	2 × [SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [Complex:R-GGA-140789] factor XIII cleaved tetramer [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
output	2 × [EntityWithAccessionedSequence:R-GGA-140605] F13B [extracellular region] [Complex:R-GGA-140849] factor XIIIa [extracellular region]
precedingEvent	[Reaction:R-GGA-140599] factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides - Gallus gallus [Reaction:R-GGA-481009] Exocytosis of platelet dense granule content - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-140847
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9769733] Fibrin formation
(precedingEvent)	[BlackBoxEvent:R-GGA-9921091] ?IIb?3:fibrin multimer ->?IIb?3:fibrin multimer, crosslinked + NH4+
(inferredTo)	[Reaction:R-HSA-140847] factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

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