Reactome | Binding of PI3K to ERBB2:p-ERBB3 heterodimer

Schema > Reaction > Entries

Binding of PI3K to ERBB2:p-ERBB3 heterodimer Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10770171
displayName	Binding of PI3K to ERBB2:p-ERBB3 heterodimer
eventOf	[Pathway:R-GGA-1963642] PI3K events in ERBB2 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Gallus gallus [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - Homo sapiens
input	[CandidateSet:R-GGA-1963572] Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] [Complex:R-GGA-1806218] PIK3CA:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of PI3K to ERBB2:p-ERBB3 heterodimer
output	[Complex:R-GGA-1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane]
precedingEvent	[Reaction:R-GGA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Gallus gallus [Reaction:R-GGA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1250189
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1963642] PI3K events in ERBB2 signaling
(precedingEvent)	[Reaction:R-GGA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer