Reactome | GBP-mediated host defense

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GBP-mediated host defense Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650780
displayName	GBP-mediated host defense
eventOf	[Pathway:R-DRE-1169410] Antimicrobial mechanism of IFN-stimulated genes - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9715851] defense response to symbiont
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-9948016] FNTA:FNTB transfers farnesyl to GBP1 - Danio rerio [Reaction:R-DRE-9947999] FNTA:PGGT1B geranylgeranylates GBP2 - Danio rerio [Reaction:R-DRE-9954195] FNTA:PGGT1B geranylgeranylates GBP5 - Danio rerio [Reaction:R-DRE-9968553] GBP1 binds GTP - Danio rerio [Reaction:R-DRE-9947932] GBP1:GTP binds LPS on the bacterial surface - Danio rerio [Reaction:R-DRE-9947887] GBP1 hydrolyzes GDP - Danio rerio [Reaction:R-DRE-9953173] GMP dissociates from the GBP1 oligomer - Danio rerio [Reaction:R-DRE-9947946] GBP2, GBP3, GBP4 bind to GBP1 oligomer on the bacterial surface - Danio rerio [Polymerisation:R-DRE-9947876] GBP1:GBP2:GBP3:GBP4 forms higher-order structures - Danio rerio [Reaction:R-DRE-9954252] GGC-GBP2, GGC-GBP5 bind furin - Danio rerio [Reaction:R-DRE-9956706] GBP1 binds actin - Danio rerio [Pathway:R-DRE-9968551] Regulation of GBP-mediated host defense - Danio rerio
inferredFrom	[Pathway:R-HSA-9953170] GBP-mediated host defense - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	GBP-mediated host defense
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-9953170
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1169410] Antimicrobial mechanism of IFN-stimulated genes
(hasEncapsulatedEvent)	[Pathway:R-DRE-9686114] Non-canonical inflammasome activation
(inferredTo)	[Pathway:R-HSA-9953170] GBP-mediated host defense

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