Reactome | FIRRM binds PLK1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10644583
displayName	FIRRM binds PLK1
eventOf	[Pathway:R-DRE-2500257] Resolution of Sister Chromatid Cohesion - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9851972] PLK1 phosphorylates FIRRM at S43 - Danio rerio
inferredFrom	[Reaction:R-HSA-9851946] FIRRM binds PLK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-9851948] firrm [cytosol] [EntityWithAccessionedSequence:R-DRE-3000318] phospho-p-T210-PLK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FIRRM binds PLK1
output	[Complex:R-DRE-9851951] FIRRM:p-T210-PLK1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9851946
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-2500257] Resolution of Sister Chromatid Cohesion
(precedingEvent)	[Reaction:R-DRE-9851972] PLK1 phosphorylates FIRRM at S43
(inferredTo)	[Reaction:R-HSA-9851946] FIRRM binds PLK1