Reactome | LONP1 degrades mitochondrial inner membrane proteins

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LONP1 degrades mitochondrial inner membrane proteins Show undefined attributes

catalystActivity	[CatalystActivity:10643441] ATP-dependent peptidase activity of LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix]
category	omitted
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10643443
displayName	LONP1 degrades mitochondrial inner membrane proteins
eventOf	[Pathway:R-DRE-9837999] Mitochondrial protein degradation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9838004] LONP1 degrades mitochondrial inner membrane proteins - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [Complex:R-DRE-9837963] LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	LONP1 degrades mitochondrial inner membrane proteins
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [Complex:R-DRE-9838005] LONP1 hexamer [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-9837978] LONP1 binds mitochondrial inner membrane proteins - Danio rerio
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:68323] Danio rerio
stId	R-DRE-9838004
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9837999] Mitochondrial protein degradation
(inferredTo)	[BlackBoxEvent:R-HSA-9838004] LONP1 degrades mitochondrial inner membrane proteins

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