Reactome | Anti-MET small tyrosine kinase inhibitors bind MET

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10641448
displayName	Anti-MET small tyrosine kinase inhibitors bind MET
eventOf	[Pathway:R-DRE-9734091] Drug-mediated inhibition of MET activation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9735946] Anti-MET small tyrosine kinase inhibitors bind MET - Homo sapiens
input	2 × [CandidateSet:R-ALL-9735962] Anti-MET TKIs [cytosol] [Complex:R-DRE-6806956] HGF:MET dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Anti-MET small tyrosine kinase inhibitors bind MET
output	[Complex:R-DRE-9735965] HGF:MET dimer:TKIs [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9735946
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-9734091] Drug-mediated inhibition of MET activation
(inferredTo)	[Reaction:R-HSA-9735946] Anti-MET small tyrosine kinase inhibitors bind MET

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