Reactome | ESR1 binds ESR1 antagonists

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10641150
displayName	ESR1 binds ESR1 antagonists
eventOf	[Pathway:R-DRE-8939211] ESR-mediated signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9716913] ESR1 binds ESR1 antagonists - Homo sapiens
input	[DefinedSet:R-ALL-9716906] ESR1 antagonists [nucleoplasm] [Complex:R-DRE-8939185] ESR1:chaperone complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ESR1 binds ESR1 antagonists
output	[Complex:R-DRE-9716943] ESR1:ESR1 antagonists [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9716913
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-8939211] ESR-mediated signaling
(inferredTo)	[Reaction:R-HSA-9716913] ESR1 binds ESR1 antagonists

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