Reactome | ESR-mediated signaling

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ESR-mediated signaling Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648668
displayName	ESR-mediated signaling
eventOf	[Pathway:R-DRE-9006931] Signaling by Nuclear Receptors - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-8939204] ESTG binds ESR1:chaperone complex - Danio rerio [Reaction:R-DRE-9716947] ESR1 binds ESR1 agonists - Danio rerio [Reaction:R-DRE-9716913] ESR1 binds ESR1 antagonists - Danio rerio [Reaction:R-DRE-9709547] ESTG binds ESR2:chaperone complex - Danio rerio [Reaction:R-DRE-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Danio rerio [Reaction:R-DRE-8939201] ESR dimerizes - Danio rerio [Reaction:R-DRE-9038029] 27-hydroxysterol binds ESR1, ESR2 - Danio rerio [Pathway:R-DRE-9018519] Estrogen-dependent gene expression - Danio rerio [Pathway:R-DRE-9009391] Extra-nuclear estrogen signaling - Danio rerio [BlackBoxEvent:R-DRE-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Danio rerio
inferredFrom	[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	ESR-mediated signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-8939211
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9006931] Signaling by Nuclear Receptors
(inferredTo)	[Pathway:R-HSA-8939211] ESR-mediated signaling

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