Reactome | PGRMC2 binds Hemes

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10640794
displayName	PGRMC2 binds Hemes
eventOf	[Pathway:R-DRE-9707616] Heme signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-9707606] PGRMC2:Hemes translocate to the nucleus - Danio rerio
inferredFrom	[Reaction:R-HSA-9707683] PGRMC2 binds Hemes - Homo sapiens
input	[CandidateSet:R-ALL-9707308] Hemes [cytosol] [EntityWithAccessionedSequence:R-DRE-9707674] pgrmc2 [nuclear envelope]
isInDisease	false
isInferred	true
maxDepth	1
name	PGRMC2 binds Hemes
output	[Complex:R-DRE-9707603] PGRMC2:Hemes [nuclear envelope]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9707683
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-9707616] Heme signaling
(precedingEvent)	[BlackBoxEvent:R-DRE-9707606] PGRMC2:Hemes translocate to the nucleus
(inferredTo)	[Reaction:R-HSA-9707683] PGRMC2 binds Hemes

Cite Us!