Reactome | Meglitinides bind ABCC8

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10639873
displayName	Meglitinides bind ABCC8
eventOf	[Pathway:R-DRE-422356] Regulation of insulin secretion - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9650858] Meglitinides bind ABCC8 - Homo sapiens
input	[Complex:R-DRE-265734] KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane] [DefinedSet:R-ALL-9650988] Meglitinides [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Meglitinides bind ABCC8
output	[Complex:R-DRE-9650859] ABCC8:Meglitinides [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9650858
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-422356] Regulation of insulin secretion
(inferredTo)	[Reaction:R-HSA-9650858] Meglitinides bind ABCC8