Reactome | Regulation of insulin secretion

Schema > Pathway > Entries

Regulation of insulin secretion Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:984] extracellular region [Compartment:5460] mitochondrial matrix [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane [Compartment:1462052] secretory granule lumen [Compartment:216813] secretory granule membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648824
displayName	Regulation of insulin secretion
eventOf	[Pathway:R-DRE-163685] Integration of energy metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:160566] regulation of insulin secretion
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DRE-400042] Adrenaline,noradrenaline inhibits insulin secretion - Danio rerio [Pathway:R-DRE-399997] Acetylcholine regulates insulin secretion - Danio rerio [Pathway:R-DRE-400451] Free fatty acids regulate insulin secretion - Danio rerio [Pathway:R-DRE-381676] Glucagon-like Peptide-1 (GLP1) regulates insulin secretion - Danio rerio [Reaction:R-DRE-499981] Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 - Danio rerio [Reaction:R-DRE-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Danio rerio [Reaction:R-DRE-9650858] Meglitinides bind ABCC8 - Danio rerio [Reaction:R-DRE-9652580] SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) - Danio rerio
inferredFrom	[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Regulation of insulin secretion
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-422356
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-163685] Integration of energy metabolism
(inferredTo)	[Pathway:R-HSA-422356] Regulation of insulin secretion