Reactome | Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

Schema > Complex > Entries

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10590309] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-DRE-927836] SMG6 hydrolyzes mRNA with premature termination codon - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10590300
displayName	Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-DRE-927856] phospho-p-4S-UPF1 [cytosol] [Complex:R-DRE-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [EntityWithAccessionedSequence:R-DRE-927867] smg5 [cytosol] [EntityWithAccessionedSequence:R-DRE-927851] smg6 [cytosol] [EntityWithAccessionedSequence:R-DRE-927838] smg7 [cytosol] [Complex:R-DRE-927773] Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] [EntityWithAccessionedSequence:R-DRE-927801] upf3a [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] - Homo sapiens
maxDepth	6
name	Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP
producedByEvent	[BlackBoxEvent:R-DRE-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-927854
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-DRE-927836] SMG6 hydrolyzes mRNA with premature termination codon
(physicalEntity)	[CatalystActivity:10590309] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
(output)	[BlackBoxEvent:R-DRE-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
(inferredTo)	[Complex:R-HSA-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

© 2026 Reactome

Cite Us!