Reactome | AP-2 directly binds some endocytic cargo

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10631532
displayName	AP-2 directly binds some endocytic cargo
eventOf	[Pathway:R-DRE-8856825] Cargo recognition for clathrin-mediated endocytosis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8866277] AP-2 directly binds some endocytic cargo - Homo sapiens
input	[DefinedSet:R-DRE-8866235] AP-2 cargo [plasma membrane] [Complex:R-DRE-167712] AP-2 Complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AP-2 directly binds some endocytic cargo
output	[Complex:R-DRE-8866238] AP-2:cargo [plasma membrane]
regulatedBy	[NegativeRegulation:10631533] Negative regulation by 'AP2:chlorpromazine [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-8866277
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-8856825] Cargo recognition for clathrin-mediated endocytosis
(inferredTo)	[Reaction:R-HSA-8866277] AP-2 directly binds some endocytic cargo

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