Reactome | Newly Formed Phosphodiester Bond Stabilized and PPi Released

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Newly Formed Phosphodiester Bond Stabilized and PPi Released Show undefined attributes

category	dissociation
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10564968
displayName	Newly Formed Phosphodiester Bond Stabilized and PPi Released
eventOf	[Pathway:R-DRE-75953] RNA Polymerase II Transcription Initiation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-73946] Abortive initiation after formation of the first phosphodiester bond - Danio rerio [BlackBoxEvent:R-DRE-75850] Addition of the third nucleotide on the nascent transcript - Danio rerio [BlackBoxEvent:R-DRE-9613497] Unwinding DNA for the nascent transcript - Danio rerio
inferredFrom	[Reaction:R-HSA-75864] Newly Formed Phosphodiester Bond Stabilized and PPi Released - Homo sapiens
input	[Complex:R-DRE-83601] Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Newly Formed Phosphodiester Bond Stabilized and PPi Released
output	[Complex:R-DRE-109878] pol II transcription complex [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-DRE-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-75864
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-75953] RNA Polymerase II Transcription Initiation
(precedingEvent)	[Reaction:R-DRE-73946] Abortive initiation after formation of the first phosphodiester bond [BlackBoxEvent:R-DRE-75850] Addition of the third nucleotide on the nascent transcript [BlackBoxEvent:R-DRE-9613497] Unwinding DNA for the nascent transcript
(inferredTo)	[Reaction:R-HSA-75864] Newly Formed Phosphodiester Bond Stabilized and PPi Released