Reactome | Orc1 is phosphorylated by cyclin A/CDK2

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Orc1 is phosphorylated by cyclin A/CDK2 Show undefined attributes

catalystActivity	[CatalystActivity:10560317] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10560319
displayName	Orc1 is phosphorylated by cyclin A/CDK2
eventOf	[Pathway:R-DRE-68949] Orc1 removal from chromatin - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin - Danio rerio
inferredFrom	[Reaction:R-HSA-68944] Orc1 is phosphorylated by cyclin A/CDK2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DRE-68559] pre-replicative complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Orc1 is phosphorylated by cyclin A/CDK2
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DRE-68943] phospho-orc1 [nucleoplasm] [Complex:R-DRE-157563] pre-replicative complex (Orc1-minus) [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-68944
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-68949] Orc1 removal from chromatin
(precedingEvent)	[Reaction:R-DRE-68946] Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
(inferredTo)	[Reaction:R-HSA-68944] Orc1 is phosphorylated by cyclin A/CDK2

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