Reactome | DNA polymerase alpha:primase binds at the origin

Schema > Reaction > Entries

DNA polymerase alpha:primase binds at the origin Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10560276
displayName	DNA polymerase alpha:primase binds at the origin
eventOf	[Pathway:R-DRE-68962] Activation of the pre-replicative complex - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin - Danio rerio
inferredFrom	[Reaction:R-HSA-68914] DNA polymerase alpha:primase binds at the origin - Homo sapiens
input	[Complex:R-DRE-68507] DNA polymerase alpha:primase [nucleoplasm] [Complex:R-DRE-68485] DNA polymerase epsilon:origin complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DNA polymerase alpha:primase binds at the origin
output	[Complex:R-DRE-68510] DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm]
precedingEvent	[Reaction:R-DRE-68916] DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin - Danio rerio [Reaction:R-DRE-68960] DNA polymerase epsilon binds at the origin - Danio rerio
regulatedBy	[PositiveRegulation:10560277] Positive regulation by 'CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-68914
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-68962] Activation of the pre-replicative complex
(precedingEvent)	[Reaction:R-DRE-68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
(inferredTo)	[Reaction:R-HSA-68914] DNA polymerase alpha:primase binds at the origin