Reactome | SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix

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SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix Show undefined attributes

catalystActivity	[CatalystActivity:10622639] choline transmembrane transporter activity of SLC44A1,2 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5460] mitochondrial matrix [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10622641
displayName	SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix
eventOf	[Pathway:R-DRE-6798163] Choline catabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-6797961] CHDH oxidises Cho to BETALD - Danio rerio
inferredFrom	[Reaction:R-HSA-6797956] SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix - Homo sapiens
input	[SimpleEntity:R-ALL-264618] Cho [cytosol] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix choline(out) + n H(+)(in) = choline(in) + n H(+)(out)
output	[SimpleEntity:R-ALL-6798162] Cho [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-DRE-444433] Cho transports from the extracellular space to the cytosol - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6797956
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-6798163] Choline catabolism
(precedingEvent)	[Reaction:R-DRE-6797961] CHDH oxidises Cho to BETALD
(inferredTo)	[Reaction:R-HSA-6797956] SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix

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