Reactome | Cho transports from the extracellular space to the cytosol

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Cho transports from the extracellular space to the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10586397] choline transmembrane transporter activity of CTL1-5 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10586399
displayName	Cho transports from the extracellular space to the cytosol
eventOf	[Pathway:R-DRE-9958517] SLC-mediated bile acid transport - Danio rerio [Pathway:R-DRE-1483191] Synthesis of PC - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-6797956] SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix - Danio rerio [Reaction:R-DRE-1483004] Cho is phosphorylated to PCho by CHK dimer - Danio rerio [Reaction:R-DRE-264622] Cho is acetylated to AcCho by CHAT - Danio rerio
inferredFrom	[Reaction:R-HSA-444433] Cho transports from the extracellular space to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-264638] Cho [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Cho transports from the extracellular space to the cytosol CTL1-5 can mediate the uptake of choline
output	[SimpleEntity:R-ALL-264618] Cho [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-444433
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1483191] Synthesis of PC [Pathway:R-DRE-9958517] SLC-mediated bile acid transport
(precedingEvent)	[Reaction:R-DRE-264622] Cho is acetylated to AcCho by CHAT [Reaction:R-DRE-6797956] SLC44A1 and SLC44A2 transport Cho from cytosol to mitochondrial matrix [Reaction:R-DRE-1483004] Cho is phosphorylated to PCho by CHK dimer
(inferredTo)	[Reaction:R-HSA-444433] Cho transports from the extracellular space to the cytosol

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