Reactome | Homologues of CASP8(1-479) [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DRE-3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] - Danio rerio [Complex:R-DRE-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] - Danio rerio [Complex:R-DRE-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Danio rerio [Complex:R-DRE-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-141156] TRAIL-mediated dimerization of procaspase-8 - Danio rerio [Reaction:R-DRE-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 - Danio rerio [Reaction:R-DRE-9823816] OPTN binds CASP8 - Danio rerio [Reaction:R-DRE-73945] FAS-mediated dimerization of procaspase-8 - Danio rerio [Reaction:R-DRE-141159] TNF-mediated dimerization of procaspase-8 - Danio rerio [Reaction:R-DRE-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10563682
displayName	Homologues of CASP8(1-479) [cytosol]
hasMember	[EntityWithAccessionedSequence:R-DRE-57031] casp20 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-DRE-57031-2] casp10 [cytosol] - Danio rerio
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] - Homo sapiens
maxDepth	2
name	Homologues of CASP8(1-479)
schemaClass	DefinedSet
species	[Species:68323] Danio rerio
stId	R-DRE-57031-3

(input)	[Reaction:R-DRE-9823816] OPTN binds CASP8 [Reaction:R-DRE-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [Reaction:R-DRE-73945] FAS-mediated dimerization of procaspase-8 [Reaction:R-DRE-141156] TRAIL-mediated dimerization of procaspase-8 [Reaction:R-DRE-75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 [Reaction:R-DRE-141159] TNF-mediated dimerization of procaspase-8
(hasComponent)	[Complex:R-DRE-3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] [Complex:R-DRE-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] [Complex:R-DRE-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Complex:R-DRE-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] [Complex:R-DRE-5637468] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] [Complex:R-DRE-9823815] OPTN:CASP8 [cytosol] [Complex:R-DRE-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Complex:R-DRE-3465443] DISC:procaspase-8 [plasma membrane] [Complex:R-DRE-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-DRE-2671817] procaspase-8 dimer [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol]

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