Reactome | Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks

Schema > Reaction > Entries

Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10619565
displayName	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis
eventOf	[Pathway:R-DRE-5693571] Nonhomologous End-Joining (NHEJ) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5693575] DNA-PKcs autophosphorylates - Danio rerio
inferredFrom	[Reaction:R-HSA-5693615] Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-DRE-62161] prkdc [nucleoplasm] [Complex:R-DRE-75906] XRCC5:XRCC6:DNA DSBs [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis
output	[Complex:R-DRE-75907] PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5693615
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-DRE-5693575] DNA-PKcs autophosphorylates
(inferredTo)	[Reaction:R-HSA-5693615] Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis

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