Reactome | activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

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activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10616173] protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] - Danio rerio [Complex:R-DRE-9657590] activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-9657603] Dual mechanism MAPK inhibitors bind MAPKs - Danio rerio [Reaction:R-DRE-5672973] MAP2Ks phosphorylate MAPKs - Danio rerio [Reaction:R-DRE-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10616170
displayName	activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
hasComponent	[DefinedSet:R-DRE-169291] MAPKs [cytosol] [DefinedSet:R-DRE-5672721] p-2S MAP2K homo/heterodimers [cytosol] [Complex:R-DRE-5672718] p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] [CandidateSet:R-DRE-5672717] RAF/MAPK scaffolds [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] - Homo sapiens
maxDepth	11
name	activated RAF:scaffold:p-2S MAP2K:MAPK complex
producedByEvent	[Reaction:R-DRE-5672978] RAF phosphorylates MAP2K dimer - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-5672723
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-DRE-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-DRE-9657603] Dual mechanism MAPK inhibitors bind MAPKs [Reaction:R-DRE-5672973] MAP2Ks phosphorylate MAPKs
(physicalEntity)	[CatalystActivity:10616173] protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(output)	[Reaction:R-DRE-5672978] RAF phosphorylates MAP2K dimer
(hasComponent)	[Complex:R-DRE-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-DRE-9657590] activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane]
(inferredTo)	[Complex:R-HSA-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]

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