Reactome | CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)

Schema > Reaction > Entries

CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) Show undefined attributes

catalystActivity	[CatalystActivity:10610226] histone H3 methyltransferase activity of CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10610228
displayName	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)
eventOf	[Pathway:R-DRE-3214858] RMTs methylate histone arginines - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5205799] CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-DRE-4657030] Histone H3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-DRE-5244789] MeR9-histone H3 [nucleoplasm]
precedingEvent	[Reaction:R-DRE-3215385] CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 - Danio rerio
regulatedBy	[PositiveRegulation:10610229] Positive regulation by 'SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5205799
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-3214858] RMTs methylate histone arginines
(inferredTo)	[Reaction:R-HSA-5205799] CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)

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