Reactome | HSF1 trimer [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DRE-5333048] HSF1:RPA [nucleoplasm] - Danio rerio [Complex:R-DRE-5082413] HSBP1:HSF1 trimer [nucleoplasm] - Danio rerio [Complex:R-DRE-5324619] HSF1 trimer:HSP90:FKBP4:PTGES3 [nucleoplasm] - Danio rerio
consumedByEvent	[Reaction:R-DRE-5082387] Phosphorylation of HSF1 at Ser230 induces transactivation - Danio rerio [Reaction:R-DRE-5082405] Phosphorylation of HSF1 at Ser326 induces transactivation - Danio rerio [Reaction:R-DRE-5324617] HSP90:FKBP4:PTGES3 binds HSF1 trimer - Danio rerio [Reaction:R-DRE-5333051] RPA1 binds HSF1 - Danio rerio [Reaction:R-DRE-3371582] HSBP1 binds HSF1 trimer - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10607040
displayName	HSF1 trimer [nucleoplasm]
hasComponent	3 × [EntityWithAccessionedSequence:R-DRE-3371416] hsf1 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-4793790] HSF1 trimer [nucleoplasm] - Homo sapiens
maxDepth	2
name	HSF1 trimer
producedByEvent	[Reaction:R-DRE-5082391] Trimerization of HSF1 in the nucleus - Danio rerio [BlackBoxEvent:R-DRE-3371527] HSF1 trimer translocates to the nucleus - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-4793790
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-5333051] RPA1 binds HSF1 [Reaction:R-DRE-5082387] Phosphorylation of HSF1 at Ser230 induces transactivation [Reaction:R-DRE-5082405] Phosphorylation of HSF1 at Ser326 induces transactivation [Reaction:R-DRE-3371582] HSBP1 binds HSF1 trimer [Reaction:R-DRE-5324617] HSP90:FKBP4:PTGES3 binds HSF1 trimer
(hasComponent)	[Complex:R-DRE-5333048] HSF1:RPA [nucleoplasm] [Complex:R-DRE-5082413] HSBP1:HSF1 trimer [nucleoplasm] [Complex:R-DRE-5324619] HSF1 trimer:HSP90:FKBP4:PTGES3 [nucleoplasm] [Complex:R-DRE-4793813] HSF1 trimer:target gene [nucleoplasm]
(output)	[Reaction:R-DRE-5082391] Trimerization of HSF1 in the nucleus [BlackBoxEvent:R-DRE-3371527] HSF1 trimer translocates to the nucleus
(inferredTo)	[Complex:R-HSA-4793790] HSF1 trimer [nucleoplasm]

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