Reactome | KDM5A-D demethylate Me2K5-histone H3

Schema > Reaction > Entries

KDM5A-D demethylate Me2K5-histone H3 Show undefined attributes

catalystActivity	[CatalystActivity:10609566] histone demethylase activity of KDM5A-D [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10609568
displayName	KDM5A-D demethylate Me2K5-histone H3
eventOf	[Pathway:R-DRE-3214842] HDMs demethylate histones - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4754181] KDM5A-D demethylate Me2K5-histone H3 - Homo sapiens
input	[SimpleEntity:R-ALL-113671] 2OG [nucleoplasm] [CandidateSet:R-DRE-2245191] H3K4me2 [nucleoplasm] [SimpleEntity:R-ALL-113685] O2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KDM5A-D demethylate Me2K5-histone H3
output	[SimpleEntity:R-ALL-29478] CH2O [nucleoplasm] [SimpleEntity:R-ALL-159942] CO2 [nucleoplasm] [CandidateSet:R-DRE-5173296] MeK5-histone H3 [nucleoplasm] [SimpleEntity:R-ALL-159939] SUCCA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-4754181
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-3214842] HDMs demethylate histones
(inferredTo)	[Reaction:R-HSA-4754181] KDM5A-D demethylate Me2K5-histone H3

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