Reactome | RANBP2 SUMOylates HDAC4 with SUMO2,3

Schema > Reaction > Entries

RANBP2 SUMOylates HDAC4 with SUMO2,3 Show undefined attributes

catalystActivity	[CatalystActivity:10605245] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10609267
displayName	RANBP2 SUMOylates HDAC4 with SUMO2,3
eventOf	[Pathway:R-DRE-4551638] SUMOylation of chromatin organization proteins - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4615987] RANBP2 SUMOylates HDAC4 with SUMO2,3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-351581] HDAC4 [nucleoplasm] 2 × [DefinedSet:R-DRE-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RANBP2 SUMOylates HDAC4 with SUMO2,3
output	[EntityWithAccessionedSequence:R-DRE-4616029] polySUMO2,3-K559-HDAC4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-DRE-912481] ube2ia [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-4615987
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-4551638] SUMOylation of chromatin organization proteins
(inferredTo)	[Reaction:R-HSA-4615987] RANBP2 SUMOylates HDAC4 with SUMO2,3

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