Reactome | IGFBP6 binds IGF forming IGF:IGFBP6

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10581929
displayName	IGFBP6 binds IGF forming IGF:IGFBP6
eventOf	[Pathway:R-DRE-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-381503] IGFBP6 binds IGF forming IGF:IGFBP6 - Homo sapiens
input	[DefinedSet:R-DRE-381475-4] Homologues of IGFBP6 [extracellular region] [DefinedSet:R-DRE-381451] IGF1,2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	IGFBP6 binds IGF forming IGF:IGFBP6
output	[Complex:R-DRE-381482] IGF:IGFBP6 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-381503
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(inferredTo)	[Reaction:R-HSA-381503] IGFBP6 binds IGF forming IGF:IGFBP6