Reactome | Formation of the IGF:IGFBP3:ALS complex

Schema > Reaction > Entries

Formation of the IGF:IGFBP3:ALS complex Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10581882
displayName	Formation of the IGF:IGFBP3:ALS complex
eventOf	[Pathway:R-DRE-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-381435] Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS - Danio rerio [Reaction:R-DRE-381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS - Danio rerio [Reaction:R-DRE-381461] Plasmin proteolyzes IGF:IGFBP-3:ALS - Danio rerio [Reaction:R-DRE-381446] Thrombin proteolyzes IGF:IGFBP3:ALS - Danio rerio
inferredFrom	[Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex - Homo sapiens
input	[DefinedSet:R-DRE-381451] IGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-DRE-381498] igfals [extracellular region] [EntityWithAccessionedSequence:R-DRE-381512] igfbp3 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of the IGF:IGFBP3:ALS complex
output	[Complex:R-DRE-381536] IGF:IGFBP3:ALS [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-381496
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(precedingEvent)	[Reaction:R-DRE-381435] Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS [Reaction:R-DRE-381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS [Reaction:R-DRE-381461] Plasmin proteolyzes IGF:IGFBP-3:ALS [Reaction:R-DRE-381446] Thrombin proteolyzes IGF:IGFBP3:ALS
(inferredTo)	[Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex