Reactome | DARPP-32 is dephosphorylated on Thr75 by PP2A

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DARPP-32 is dephosphorylated on Thr75 by PP2A Show undefined attributes

catalystActivity	[CatalystActivity:10575995] protein serine/threonine phosphatase activity of PP2A-ABdeltaC complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10575997
displayName	DARPP-32 is dephosphorylated on Thr75 by PP2A
eventOf	[Pathway:R-DRE-180024] DARPP-32 events - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-DRE-180053] phospho-ppp1r1b [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DARPP-32 is dephosphorylated on Thr75 by PP2A
output	[DefinedSet:R-DRE-180056] DARPP-32 (and/or phosphorylated) [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-DRE-180047] CDK5 phosphorylates DARPP-32 on Thr75 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-201790
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-180024] DARPP-32 events
(inferredTo)	[Reaction:R-HSA-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A

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