Reactome | CDK5 phosphorylates DARPP-32 on Thr75

Schema > Reaction > Entries

CDK5 phosphorylates DARPP-32 on Thr75 Show undefined attributes

catalystActivity	[CatalystActivity:10572411] cyclin-dependent protein serine/threonine kinase activity of CDK5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572413
displayName	CDK5 phosphorylates DARPP-32 on Thr75
eventOf	[Pathway:R-DRE-180024] DARPP-32 events - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A - Danio rerio [Reaction:R-DRE-180073] DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function - Danio rerio
inferredFrom	[Reaction:R-HSA-180047] CDK5 phosphorylates DARPP-32 on Thr75 - Homo sapiens
input	[DefinedSet:R-DRE-180056] DARPP-32 (and/or phosphorylated) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK5 phosphorylates DARPP-32 on Thr75
output	[EntityWithAccessionedSequence:R-DRE-180053] phospho-ppp1r1b [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-180047
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-180024] DARPP-32 events
(precedingEvent)	[Reaction:R-DRE-201790] DARPP-32 is dephosphorylated on Thr75 by PP2A [Reaction:R-DRE-180073] DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
(inferredTo)	[Reaction:R-HSA-180047] CDK5 phosphorylates DARPP-32 on Thr75

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