Reactome | S2P hydrolyzes SREBP1A,1C,2

Schema > Reaction > Entries

S2P hydrolyzes SREBP1A,1C,2 Show undefined attributes

catalystActivity	[CatalystActivity:10584526] metalloendopeptidase activity of MBTPS2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10597273
displayName	S2P hydrolyzes SREBP1A,1C,2
eventOf	[Pathway:R-DRE-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2065549] SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers - Danio rerio
inferredFrom	[Reaction:R-HSA-1655851] S2P hydrolyzes SREBP1A,1C,2 - Homo sapiens
input	[DefinedSet:R-DRE-1655726] SREBF1A,1C,2 cleaved by S1P [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	S2P hydrolyzes SREBP1A,1C,2 S2P hydrolyzes SREBF1A,1C,2
output	[DefinedSet:R-DRE-1655732] SREBF1A,1C,2 cleaved by S2P [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1655851
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)
(precedingEvent)	[Reaction:R-DRE-2065549] SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers
(inferredTo)	[Reaction:R-HSA-1655851] S2P hydrolyzes SREBP1A,1C,2

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