Reactome | Regulation of cholesterol biosynthesis by SREBP (SREBF)

Schema > Pathway > Entries

Regulation of cholesterol biosynthesis by SREBP (SREBF) Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:13945] ER to Golgi transport vesicle membrane [Compartment:20699] Golgi membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649550
displayName	Regulation of cholesterol biosynthesis by SREBP (SREBF)
eventOf	[Pathway:R-DRE-8957322] Metabolism of steroids - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23584] regulation of cholesterol biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DRE-1655851] S2P hydrolyzes SREBP1A,1C,2 - Danio rerio [Reaction:R-DRE-2065549] SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers - Danio rerio [Reaction:R-DRE-2065550] SREBP1A,1C,2 binds Importin beta-1 - Danio rerio [BlackBoxEvent:R-DRE-1655831] SREBP1A,1C,2 translocates to the nucleus - Danio rerio [Reaction:R-DRE-2065539] SREBP1A,1C,2:Importin beta-1 dissociates - Danio rerio
inferredFrom	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of cholesterol biosynthesis by SREBP (SREBF)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-1655829
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8957322] Metabolism of steroids
(inferredTo)	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)

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