Reactome | Activation of BH3-only proteins

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648060
displayName	Activation of BH3-only proteins
eventOf	[Pathway:R-DRE-109606] Intrinsic Pathway for Apoptosis - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5673453] positive regulation of protein localization to mitochondrion
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DRE-111447] Activation of BAD and translocation to mitochondria - Danio rerio [Pathway:R-DRE-111448] Activation of NOXA and translocation to mitochondria - Danio rerio
inferredFrom	[Pathway:R-HSA-114452] Activation of BH3-only proteins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Activation of BH3-only proteins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-114452
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-109606] Intrinsic Pathway for Apoptosis
(inferredTo)	[Pathway:R-HSA-114452] Activation of BH3-only proteins

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