Reactome | Activation of NOXA and translocation to mitochondria

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648064
displayName	Activation of NOXA and translocation to mitochondria
eventOf	[Pathway:R-DRE-114452] Activation of BH3-only proteins - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5673453] positive regulation of protein localization to mitochondrion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-140216] Translocation of PMAIP1 (NOXA) to mitochondria - Danio rerio
inferredFrom	[Pathway:R-HSA-111448] Activation of NOXA and translocation to mitochondria - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activation of NOXA and translocation to mitochondria
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-111448
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-114452] Activation of BH3-only proteins
(inferredTo)	[Pathway:R-HSA-111448] Activation of NOXA and translocation to mitochondria

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