Reactome | Release of SMAC (DIABLO) from mitochondria

Schema > Reaction > Entries

Release of SMAC (DIABLO) from mitochondria Show undefined attributes

category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10567467
displayName	Release of SMAC (DIABLO) from mitochondria
eventOf	[Pathway:R-DRE-111457] Release of apoptotic factors from the mitochondria - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-DRE-111469] SMAC, XIAP-regulated apoptotic response - Danio rerio [Pathway:R-DRE-111463] SMAC (DIABLO) binds to IAPs - Danio rerio [Reaction:R-DRE-9627350] SMAC (DIABLO) binds XIAP - Danio rerio [Reaction:R-DRE-9627106] SMAC (DIABLO) forms dimer - Danio rerio [Reaction:R-DRE-114354] SMAC binds XIAP:Caspase-7 - Danio rerio
inferredFrom	[Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-64637] diabloa [mitochondrial intermembrane space]
isInDisease	false
isInferred	true
maxDepth	1
name	Release of SMAC (DIABLO) from mitochondria
output	[EntityWithAccessionedSequence:R-DRE-114298] diabloa [cytosol]
precedingEvent	[Reaction:R-DRE-114275] Oligomerization of BAX at the mitochondrial membrane - Danio rerio [Reaction:R-DRE-139920] Translocation of tBID to mitochondria - Danio rerio
regulatedBy	[PositiveRegulation:10567458] Positive regulation by 'Activated BAX,BAK oligomers [mitochondrial outer membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-114307
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-DRE-111469] SMAC, XIAP-regulated apoptotic response [Pathway:R-DRE-111463] SMAC (DIABLO) binds to IAPs [Reaction:R-DRE-9627350] SMAC (DIABLO) binds XIAP [Reaction:R-DRE-9627106] SMAC (DIABLO) forms dimer [Reaction:R-DRE-114354] SMAC binds XIAP:Caspase-7
(hasEvent)	[Pathway:R-DRE-111457] Release of apoptotic factors from the mitochondria
(inferredTo)	[Reaction:R-HSA-114307] Release of SMAC (DIABLO) from mitochondria