Reactome | SMAC, XIAP-regulated apoptotic response

Schema > Pathway > Entries

SMAC, XIAP-regulated apoptotic response Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648024
displayName	SMAC, XIAP-regulated apoptotic response
eventOf	[Pathway:R-DRE-111471] Apoptotic factor-mediated response - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-9627104] XIAP binds CASP3 - Danio rerio [Reaction:R-DRE-9627107] XIAP binds CASP7 - Danio rerio [Pathway:R-DRE-111463] SMAC (DIABLO) binds to IAPs - Danio rerio [Pathway:R-DRE-111464] SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes - Danio rerio [Reaction:R-DRE-9627369] SEPT4 binds XIAP - Danio rerio
inferredFrom	[Pathway:R-HSA-111469] SMAC, XIAP-regulated apoptotic response - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	SMAC, XIAP-regulated apoptotic response
precedingEvent	[Reaction:R-DRE-114307] Release of SMAC (DIABLO) from mitochondria - Danio rerio
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-111469
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-111471] Apoptotic factor-mediated response
(inferredTo)	[Pathway:R-HSA-111469] SMAC, XIAP-regulated apoptotic response

Cite Us!