Reactome | Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)

Schema > BlackBoxEvent > Entries

Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst) Show undefined attributes

catalystActivity	[CatalystActivity:10909011] endopeptidase activity of PA28-alpha-beta-20S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10909013
displayName	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)
eventOf	[Pathway:R-DME-9912633] Antigen processing: Ub, ATP-independent proteasomal degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DME-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Drosophila melanogaster
inferredFrom	[BlackBoxEvent:R-HSA-9912636] Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst) - Homo sapiens
input	[OtherEntity:R-ALL-983035] antigenic substrate [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)
output	[SimpleEntity:R-ALL-8955634] oligopeptide fragment (3-7aa) [cytosol] [SimpleEntity:R-ALL-983032] oligopeptide fragment (8-16aa) [cytosol] [SimpleEntity:R-ALL-983036] precursor peptide fragment (>16 aa) [cytosol]
precedingEvent	[Reaction:R-DME-9908709] Formation of the PA28-alpha-beta-20S proteasome - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9912636
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9912633] Antigen processing: Ub, ATP-independent proteasomal degradation
(precedingEvent)	[BlackBoxEvent:R-DME-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
(inferredTo)	[BlackBoxEvent:R-HSA-9912636] Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)

Cite Us!